成都中医药大学基础医学院研究员王勇

个人简介

       王勇  博士，留美博士后，研究员，硕士生导师。2007年10至2009年07月，在美国印第安纳大学医学院进行博士研究生联合培养；2011年获得四川大学博士学位；2011年11月至2012年10月，在美国奥尔巴尼医学院从事博士后研究工作；2012年11月至2017年02月，在美国奥古斯塔大学从事博士后/研究员工作；2017年03被成都中医药大学海外高层次留学人才引进回国，在成都中医药大学基础医学院工作。主要研究方向：心血管发育、病理性血管重塑、血管再生及血管炎症、肌肉损伤后的再生、中医药对心血管疾病的作用及机理。科研项目：实验室已经建立分子生物学实验平台，病理学实验平台，并与国内外多家实验室保持长期合作。已完成国家自然科学基金委员会项目3项。目前承担国家自然科学基金委员会面上项目1项，四川省青年科技创新研究团对项目1项，成都中医药大学“杏林学者”学科人才科研提升计划拔尖人才项目1项。研究成果已在Circulation Research, Nature Communications, EMBO MM, PNAS, ATVB, JBC, Br J Pharmacol等杂志发表。

代表性成果

1.Yong Wang, Yiming Xu, Siyuan Yan, Kaixiang Cao, Xianqiu Zeng, Yaqi Zhou, Zhiping Liu, Qiuhua Yang, Yue Pan, Xiaoling Wang, DetlevBoison, YunchaoSu,Xuejun Jiang, Vijay S Patel, David Fulton, Neal L. Weintraub, YuqingHuo. Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. Cardiovascular Research.2020. https://doi.org/10.1093/cvr/cvaa040

2.Huan Yao, Ziqiang Wu, Yiming Xu, Huan Xu, Guanhua Lou, Qing Jiang, Weichuan Fan, Weiming Liu, Chuan Zheng, Yongxiang Gao, Yong Wang. Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway. Scientifi Reports. 2019.9(1):4968 | https://doi.org/10.1038/s41598-019-41417-5

3.YimingXu,Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou, Xianqiu Zeng, Zhiping Liu, Xiaofei An, HaroldoA.Toque, Zheng Dong, Xuejun Jiang,  David J.Fulton, Neal L.Weintraub, Qinkai Li, ZsoltBagi, Mei Hong, DetlevBoison, Chaodong Wu, YuqingHuo. Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nature Communications. 2017.8(1):943

4.Yiming Xu, Yong Wang, Siyuan Yan, Yaqi Zhou, Qiuhuan Yang, Yue Pan, Xuanqiu Zeng, XiaofeiAn, Zhiping Liu, Lina Wang, Jiean Xu, Yapeng Cao, David J Fulton, Neal L Weintraub, ZsoltBagi, NasrulHoda, Xiaoling Wang, Qinkai Li, Mei Hong, Xuejun Jiang, DetlevBoison, Christian Weber, Chaodong Wu, YuqingHuo. Intracellular adenosine alters epigenetic programming in endothelial cells to promote angiogenesis. EMBO MM. 2017. 9(9):1263-1278

5.Yong Wang, Guoqing Hu, Fang Liu, Xiaobo Wang, Mingfu Wu, John J. Schwarz, Jiliang Zhou. Deletion of YAP specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circulation Research. 2014. 114: 957-965.

6.Fang Liu, Xiaobo Wang, Guoqing Hu, Yong Wang, Jiliang Zhou. The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function. J Biol Chem. 2014. 289(6): 3308-16

7.Yiming Xu, XiaofeiAn, Xin Guo, TsadikHabtetsion, Yong Wang, Xizhen Xu, Sridhar Kandala, Qinkai Li, Honggui Li, Chunxiang Zhang, Ruth B. Caldwell, David J. Fulton, Yunchao Su, MdNasrulHoda, Gang Zhou, Chaodong Wu, YuqingHuo. Endothelial 6-phosphofructo-2-kinase (PFKFB3) plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol. 2014. 34(6): 1231-9

8.Xiaobo Wang, Guoqing Hu, Xiangwei Gao, Yong Wang, Wei Zhang, Erin Yun Harmon, Xu Zhi, Zhengping Xu, Michelle R. Lennartz, Margarida Barroso, Mohamed Trebak, Ceshi Chen, Jiliang Zhou. The induction of YAP expression following arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2662-9

9.Wenjun Zhang, Hanyin Chen, Yong Wang, Weidong Yong, Wuqiang Zhu, Yunlong Liu, Gregory R. Wagner, R. Mark Payne, Loren J Field, Hongbo Xin, ChenlengCai, WeinianShou. Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function. J Biol Chem. 2011. 286(42): 36820-9

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