赣南医学院药学院博士教授硕士生导师学者吴龙火

吴龙火：男，博士，教授，硕士生导师，江西省青年井冈学者，江西省百千万人才工程人选，赣州市优秀科技工作者。制药工程、药物化学教研室主任，生药学重点学科带头人。2015-2016获国家CSC公派到美国布朗大学进修访问1年。主持国家自然科学基金项目4项，主持参与江西省科技厅自然科学基金项目5项，江西省教育厅科技项目8项，江西省教改课题1项，获江西省自然科学奖三等奖1项；授权专利4项，发表SCI论文近 50篇。

研究兴趣：  

（1）骨与软骨疾病研究；（2）天然产物活性成分研究。  

发表论文（近3年）：  

1. Yizhou Zheng, Rui Zhang, Weimei Shi, Linfu Li, Hai Liu, Zhixi Chen, Longhuo Wu*. The metabolism and pharmacological activities of the natural health-benefiting compound diosmin. Food Function. 2020. doi: 10.1039/d0fo01598a.

2. Hao Huang, Yizhou Zheng, Linfu Li, Weimei Shi, Rui Zhang, Hai Liu, Zhixi Chen, Longhuo Wu*. The roles of post-translational modifications and coactivators of STAT6 signaling in tumor growth and progression. Future Med Chem. 2020. doi: 10.4155/fmc-2020-0224.

3. Linfu Li, Renbing Shi, Weimei Shi, Rui Zhang, Longhuo Wu*. Oxysophocarpine protected airway epithelial cells against apoptosis by inhibition of miR-155 expression and amelioration of MAPK and NF-κB signaling pathways. Future Med Chem. 2020, 12(16): 1475–1487.

4. Xiaohua Guo, Zhaowen Liu, Yizhou Zheng, Yamei Li, Linfu Li, Hai Liu, Zhixi Chen, Longhuo Wu*. Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors. Drug Des Devel Ther, 2020, 14:1057-1081.

5. Zhixi Chen, Rui Zhang, Weimei Shi, Linfu Li, Hai Liu, Zhiping Liu, Longhuo Wu*. The multifunctional benefits of natural occurring delphinidin and its glycosides. Journal of Agricultural and Food Chemistry. 2019, 67(41): 11288-11306.

6. Xianhua Huang, Zhixi Chen, Weimei Shi, Rui Zhang, Linfu Li, Hai Liu, Longhuo Wu*. TMF inhibits miR-29a/Wnt/β-catenin signaling through up regulating Foxo3a activity in osteoarthritis chondrocytes. Drug Design, Development and Therapy. 2019, 13: 2009-2019.

7. Jianhong Zhang, Zhixi Chen, Xianhua Huang, Linfu Li, Weimei Shi, Rui Zhang, Meiling Chen, Zhiping Liu, Daohua Xu, Longhuo Wu*. Insights in the multifunctional activities of magnolol. BioMed Research International. 2019, 2019, 1847130.

8. Weimei Shi, Zhixi Chen, Linfu Li, Hai Liu, Rui Zhang, Qilai Cheng, Daohua Xu, Longhuo Wu*. Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells. J Cancer. 2019, 10(9):2035-2046.

9. Baocheng Xie, Jiahuan Wu, Yongmei Li, Xuejun Wu, Zhanwei Zeng, Chenhui zhou, Daohua Xu, Longhuo Wu*. Geniposide alleviates glucocorticoid-induced inhibition of osteogenic differentiation in MC3T3-E1 Cells by ERK pathway. Frontiers in Pharmacology. 2019, 10:411.

10. Rui Zhang, Weimei Shi, Linfu Li, Xianhua Huang, Daohua Xu, Longhuo Wu*. The biological activity of psoralidin contributes to health. Pharmazie. 2019, 74(2): 67-72.

11. Qilai Cheng, Meixiang Liao, Hongliang Li, Longhuo Wu*. Asiatic acid (AA) sensitizes A549/DDP multidrug-resistant human lung adenocarcinoma cells to cisplatin (DDP) via downregulation of P-glycoprotein (P-gp) and its regulated targets. Cell Physiol Biochem 2018;47:279-292.

12. Weimei Shi, Linfu Li, Yechun Ding, Kai Yang, Zhixi Chen, Xiaona Fan, Shan Jiang, Yingjie Guan, Zhiping Liu, Daohua Xu, Longhuo Wu*. The critical role of epigallocatechin gallate in regulating mitochondrial metabolism. Future Med Chem. 2018, 10(7):795-809.

13. Longhuo Wu*, Haiqing Liu, Linfu Li, Daohua Xu, Yun Gao, Yingjie Guan, Qian Chen. 5,7,3’,4’-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway. Connect Tissue Res. 2018, 59(2): 157-166.

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