成都中医药大学特聘教授、博士生导师石三军

个人简介

石三军，博士、特聘教授、博士生导师、哈佛医学院留学归国；担任药剂学著名SCI期刊Curr Pharm Design（IF=2.2）客座主编、J Tumor编委、《现代肿瘤医学》青年编委、世中联肿瘤精准医学专委会理事等学术职务；专注于传统脂质材料、新型安全材料在核酸蛋白药物递释上的应用基础研究，其中开发的超分子复合物技术包载核酸药物被多位国际著名学者评价为首次报道。主要研究方向(1)核酸药物智能递释系统设计、(2)基于仿生生物材料的新型纳米药物构建、及在中药交叉学科中的应用、(3)肿瘤的多维靶向（3D）治疗；作为负责人主持了国家科技重大专项“重大新药创制”(726万)、国家自然科学基金等项目5项，申请发明专利2项，参编英文专著1部；以第一作者(含共同)或通讯作者身份在Angew Chem Int Edit, Biomaterials, Chemical Engineering Journal, J Control Release等杂志上发表SCI论文17篇，其中IF>10的论文3篇，共被引用1000余次。成果“新型药物制剂关键技术创新与应用”获得四川省科技进步奖1项、重庆市科协自然科学优秀学术论文奖等学术奖项、相关成果多次受邀参加国内外学术会议专题报告；International Journal of Biological Macromolecules“杰出审稿人”。

代表性成果

1.Xili Lu#, Sanjun Shi#, Hanmei Li, Ethan Gerhard, Zhihui Lu, Xinyu Tan, Wenliang Li, Kevin M.Rahn, Denghui Xie, Guodong Xu, Fang Zou, Xiaochun Bai, Jinshan Guo, JianYang. Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives. Biomaterials, 2020; 232: 119719. (共同一作，IF=10.317).

2.Lili Wei, Chenyuan Wang, Xianjue Chen, Bing Yang, Kun Shi, Leah R. Benington, Lee Yong Lim, Sanjun Shi*, Jingxin Mo*. Dual-responsive, methotrexate-loaded, ascorbic acid-derived micelles inhibit NF-κB signaling to exert anti-tumor and anti-metastasis effects in an orthotopic mouse model of human choriocarcinoma. Theranostics. 2019; 9(15): 4354-4374. (IF=8.579).

3.Sanjun Shi, Na Kong, Chan Feng, Aram Shajii, Claire Bejgrowicz, Wei Tao*, Omid C. Farokhzad*. Drug Delivery Strategies for the Treatment of Metabolic Diseases. Advanced Healthcare Materials. 2019, 1801655. (IF=7.367).

该成果受到MaterialsViews新闻报道. https://www.materialsviewschina.com/2019/07/38598

4.Yuanyuan Li#, Sanjun Shi#, Yue Ming, Linli Wang, Chenwen Li, Minghe Luo, Ziwei Li, Bin Li, Jianhong Chen. Specific cancer stem cell-therapy by albumin nanoparticles functionalized with CD44-mediated targeting. Journal of Nanobiotechnology. 2018; 16: 99. (共同一作，IF=6.518).

5.Minghe Luo, Yue Ming, Linli Wang, Yuanyuan Li, Bin Li, Jianhong Chen, Sanjun Shi*. Local delivery of deep marine fungus-derived equisetin from polyvinylpyrrolidone (PVP) nanofibers for anti-MRSA activity. Chemical Engineering Journal. 2018; 350: 157-163. (IF=10.652).

该成果受到国际权威新闻网“Advanced in Engineering (AIE)”亮点报道. https://advanceseng.com/local-delivery-of-deep-marine-fungus-derived-equisetin-from-pvp-nanofibers-for-anti-mrsa-activity.

6.Sanjun Shi, Likai Yang, Qiu’e Yao, Xin Li, Yue Ming, Yu Zhao. Ascorbic palmitate as a bifunctional drug and nanocarrier of paclitaxel for synergistic anti-tumor therapy. Journal of Biomedical Nanotechnology.2018; 14: 1601-1612. (IF=4.483).

7.Sanjun Shi, Yuanyuan Li, Yue Ming, Chenwen Li, Ziwei Li, Jianhong Chen and Minghe Luo*. Biological activity and chemical composition of the endophytic fungus Fusarium sp. TP-G1 obtained from the root of Dendrobium officinale Kimura et Migo. Records of Natural Products. 2018; 12(6): 549-556. (IF=1.268).

8.Min Zhou, Xin Li, Yuanyuan Li, Qiu’e Yao, Yue Ming, Ziwei Li, Laichun Lu, Sanjun Shi*. Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy. Drug Delivery. 2017; 24: 1230-1242. (IF=4.9).

9.Min Hu, Chenwen Li, Xin Li, Min Zhou, Jianbin Sun, Fangfang Sheng, Sanjun Shi*, Laichun Lu*. Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibers for improved antibacterial activity. Artificial Cells, Nanomedicine, and Biotechnology. 2018; 46: 1248-1257. (IF=3.343).

10.Hanmei Li, Tao Liu, Yuxuan Zhu, Qiang Fu, Wanxia Wu, Jie Deng, Li Lan, Sanjun Shi*. An in situ-forming phospholipid-based phase transition gel prolongs the duration of local anesthesia for ropivacaine with minimal toxicity. Acta Biomaterialia 2017; 58, 136-145. (IF=7.242).

11.Yue Ming, Yuanyuan Li, Haiyan Xing, Minghe Luo, Ziwei Li, Jianhong Chen, Jingxin Mo and Sanjun Shi*. Circulating Tumor Cells: from Theory to Nanotechnology-Based Detection. Frontiers in Pharmacology 2017; 8: 35. (IF=4.225).

12.Sanjun Shi*, Min Zhou, Xin Li, et. al. Synergistic active targeting of dually integrin αvβ3/CD44-targeted nanoparticles to B16F10 tumors located at different sitxes of mouse bodies. J Control Release, 2016; 235: 1-13. (IF=7.73).

该成果受到X-Mol化学综合专业网站的亮点报道(Highlight). https://www.x-mol.com/news/3142.

13.Sanjun Shi, Lu Han, Tao Gong, Zhirong Zhang, Xun Sun. Systemic delivery of microRNA-34a for cancer stem cell therapy. Angew Chem Int Edit, 2013; 52(14): 3901-3905. (IF=12.959).

14.Sanjun Shi, Lu Han, Li Deng, Yanling Zhang, Hongxin Shen, Tao Gong, Zhirong Zhang, Xun Sun. Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. J Control Release, 2014; 194(28): 228-237. (IF=7.7).

15.Sanjun Shi, Zhirong Zhong, Jie Liu, Zhirong Zhang, Xun Sun, Tao Gong. Solid lipid nanoparticles loaded with AMOs for suppression of microRNA-21 functions in human lung cancer cells. Pharm Res, 2012; 29(1): 97-109. (IF=3.24).

联系方式：

成都中医药大学科技楼西耳房1楼

Email：shisanjuns@163.com

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